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dolor-reishiSixty-six patients affected by FM from different cities of Spain were subjected to a randomized double-blind clinical trial.

The experimental group received 3 grams of microground powdered reishi twice a day for six weeks (once at breakfast and once at dinner) while the other group was given the same quantity of an active placebo.

An initial measurement, prior to the treatment with reishi, and a final measurement after 6 weeks of treatment were made; a follow-up measurement was carried out 3 weeks after the end of the treatment.

Each measurement consisted of: questionnaires regarding Health Related Quality of Life (HRQOL), a test to measure physical condition and pain.


According to the results of the study, the group that took reishi improved the following aspects with respect to those that did not take it:

1. Inability, evaluated with the fibromyalgia impact questionnaire (FIQ). People who took reishi had a greater ability to perform their daily tasks at home and at work (such as shopping, etc).

2. Sleep, evaluated through the Health Related Quality of Life (HRQOL) questionnaire. People who took reishi were able to sleep better.

3. Happiness, assessed using the general happiness scale that measures the degree of happiness from 1 (not happy) to 7 (very happy). After taking the reishi the people felt happier, possibly due to the sleep and symptoms improvement.

4. The global clinical scale, a scale that evaluates the degree of improvement from 1 (much better) to 7 (much worse). After the treatment, the people who took reishi felt better with respect to those who did not take it.

5. Aerobic resistance, speed and flexibility of the lower limbs, assessed by means of the 6-minute walking test, after walking 20 meters at maximum speed, sitting on a chair and trying to reach beyond the tip of the foot.

In addition, the results of the study have shown that reishi could be effective in reducing:

1. Degree of pain, assessed through an analog scale of pain.

The results of the study have been published in the following media:

  •     Pazzi F. Effects of reishi (Ganoderma lucidum) in patients with fibromyalgia. Doctorate. University of Extremadura 2016. Dehesa, Institutional Repository, University of Extremadura. Available at:
  •     Collado Mateo D, Pazzi F, Dominguez Munoz FJ, et al. Ganoderma lucidum improves physical fitness in women with fibromyalgia. Nutr Hosp 2015; 32 (n05): 2126-35. Link to publication


Main bibliographical references:

Wolfe F, Smythe HA, Yunus MB, et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis and rheumatism 1990; 33(2): 160-72.

Bennett RM. Clinical manifestations and diagnosis of fibromyalgia. Rheumatic diseases clinics of North America 2009; 35(2): 215-32.

Bennett RM, Jones J, Turk DC, Russell IJ, Matallana L. An internet survey of 2,596 people with fibromyalgia. BMC musculoskeletal dis. 2007; 8: 27.

Cui XY, Cui SY, Zhang J, et al. Extract of G. lucidum prolongs sleep time in rats. Journal of ethnopharmacology 2012; 139(3): 796-800.

Lai CY, Hung JT, Lin HH, et al. Immunomodulatory and adjuvant activities of a polysaccharide extract of Ganoderma lucidum in vivo and in vitro. Vaccine 2010; 28(31): 4945-54.

Yu L, Wei H. The Hypnotic and Sedative Actions of the Spores of G. lucidum (Curt.: Fr.) P. Karst. (Aphylloph.) in Mice. 2000; 2(4): 6.

Batra P, Sharma AK, Khajuria R. Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. International journal of medicinal mushrooms 2013; 15(2): 127-43.

Chang ST, Buswell JA. Medicinal mushrooms - a prominent source of nutriceuticals for the 21st century. Current Topics in Nut. Res. 2003; 1(4): 257-80.

Han C. Antinociceptive Activity of Agaricoglycerides Extracted from Mycelium of Ling Zhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae). 2010; 12(3): 273-8.

Wachtel-Galor S, Yuen J, Buswell JA, Benzie IFF. Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom. In: Benzie IFF, Wachtel-Galor S, eds. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd ed. Boca Raton (FL); 2011.